TR Knight as George O'Malley
One of the biggest on this list, at the end of season five, George had just decided to enlist as a trauma surgeon in the army and was about to do so when he saved a woman from being hit by a bus , only to be beaten himself. He was so bad when he got to the hospital that no one recognized him until he used his finger to write his nickname, 007, on Meredith's hand. They could not save him, and he died tragically.
After several tumultuous seasons behind the scenes (including Isaiah Washington using the f-word while supposedly referring to him), Knight struggled with some of George's storylines and the fact that George barely appeared at the start of the fifth season, and asked to be released from his contract.
Knight returned to Shondaland in 2017 for an arc The catchand has also appeared in the good wife, 22.11.63i genius, among other series. In 2019, he appeared in The bravest knight and in 2020, appeared in the HBO Max series The flight attendant with Kaley Cuoco. He also returned to of Grey for an episode to meet Meredith during her COVID-19 coma.
